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Publications - Altitude

CASE Medicine publications related to high altitude medicine and physiology:

PAPERS AND REVIEWS

Grocott MPW, Levett DZH, Martin DS, Wilson M, McKenney A, Dhillon S, Montgomery H, Mythen MG and Mitchell K for the Caudwell Xtreme Everest Research Group.
Caudwell Xtreme Everest: an overview.
Advances in Experimental Medicine and Biology (in press)

Levett DZ, Fernandez BO, Riley HL, Martin DS, Mitchell K, Leckstrom CA, Ince C, Whipp BJ, Mythen MG, Montgomery HE, Grocott MP, Feelisch M, for the Caudwell Extreme Everest Research Group.
The role of nitrogen oxides in human adaptation to hypoxia.
Scientific Reports 2011;1:109

Wilson MH, Mark Edsell M, Davagnanam I, Hirani SP, Martin D, Levett DZH, Thornton J, Golay X, Strycharczuk L, Newman S; Montgomery H; Grocott MPW and Imray CHE for the Caudwell Xtreme Everest Research Group.
Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia ? an ultrasound and MRI study.
Journal of Cerebral Blood Flow and Metabolism 2011;31(10):2019-2029

Wilson MH, Levett DZ, Dhillon S, Mitchell K, Morgan J, Grocott MP, Imray C.
Stroke at high altitude diagnosed in the field using portable ultrasound.
Wilderness and Environmental Medicine 2011;22(1):54-7

Rodway GW, Edsell ME, Wong B, Windsor JS; Caudwell Xtreme Everest Research Group.
Sleep at Altitude: A Comparison of Therapies.
Wilderness Environ Med. 2011 Oct 7 (Epub ahead of print)

McMorrow RCN, Windsor JS, Mythen MG, Grocott MPW, Caudwell Xtreme Everest Research Group.
A novel ambulatory closed circuit breathing system for use during exercise.
Anaesthesia 2011 Mar 28. doi: 10.1111/j.1365-2044.2011.06698.x.

Holloway CJ, Montgomery HE, Murray AJ, Cochlin LE, Codreanu I, Hopwood N, Johnson AW, Rider OJ, Levett DZ, Tyler DJ, Francis JM, Neubauer S, Grocott MP, Clarke K; for the Caudwell Xtreme Everest Research Group.
Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp.
FASEB Journal 2011;25(2):792-796

Levett DZH, Martin DS, Wilson MH, Mitchell K, Dhillon S, Rigat F, Montgomery HE, Mythen MG, Grocott MPW; for the Caudwell Xtreme Everest Research Group.
Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia.
BMC Medical Research Methodology 2010 Oct 21;10(1):98. (Epub ahead of print)

Edwards LM, Murray AJ, Tyler DJ, Kemp GJ, Holloway CJ, Robbins PA, Neubauer S, Levett D, Montgomery HE, Grocott MP, Clarke K for the Caudwell Xtreme Everest Research Group.
The Effect of High-Altitude on Human Skeletal Muscle Energetics: 31P-MRS Results from the Caudwell Xtreme Everest Expedition.
PLoS ONE 2010;5(5):e10681

Martin DS, Goedhart P, Vercueil A, Ince C, Levett DZH, Grocott MPW for the Caudwell Xtreme Everest Research Group.
Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude.
Experimental Physiology 2010;95:880-891

Grocott MP, Martin DS, Wilson MH, Mitchell K, Dhillon S, Mythen MG, Montgomery HE, Levett DZ; Caudwell Xtreme Everest Research Group.
Caudwell Xtreme Everest Expedition.
High Altitude Medicine and Biology 2010;11(2):133-7

Murray AJ.
Metabolic adaptation of skeletal muscle to hypoxia: how new technologies could resolve the controversies
Genome Medicine 2009;18;1(12):117

Martin DS, Levett DZH, Grocott MP, Montgomery H.
Variation in human performance in the hypoxic mountain environment.
Experimental Physiology 2010;95(3):463-70

Martin D, Levett DZH, Mythen M, Grocott MPW for the Caudwell Xtreme Everest Research Group.
Changes in skeletal muscle oxygenation during exercise measured by near infra-red spectroscopy on ascent to altitude.
Critical Care 2009;13(Suppl 5):S7

Grocott M, Martin D, Levett D, McMorrow R, Windsor J, Montgomery H for the Caudwell Xtreme Everest Research Group..
Arterial blood gases and oxygen content in climbers on Mount Everest.
New England Journal of Medicine 2009;360:140-149

Bezemer R, Karemaker JM, Klijn E, Martin D, Mitchell K, Grocott M, Heger M, Ince C.
Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge.
Critical Care 2009;13(Suppl 5):S5

Scrase E, Laverty A, Gavlak JC, Sonnappa S, Levett DZ, Martin D, Grocott MP, Stocks J.
The Young Everest Study: Effects of hypoxia at high altitude on cardio-respiratory function and general well-being in healthy children.
Archives of Diseases in Children. 2009;94(8):621-6

Martin DS, Ince C, Goedhart P, Levett DZ, Grocott MP for the Caudwell Xtreme Everest Research Group.
Abnormal blood flow in the sublingual microcirculation at high altitude.
European Journal of Applied Physiology. 2009;106:473?478

Khosravi M, Grocott MPW.
Mountainside to bedside: reality or fiction?
Expert Review of Respiratory Medicine. 2009;3(6):561-565

Imray C, Grieve A, Dhillon S, Caudwell Xtreme Everest Research Group
Cold damage to the extremities: frostbite and non-freezing cold injuries
Post Graduate Medical Journal 2009;85(1007):481-6

Grocott MP.
Human physiology in extreme environments: lessons from life at the limits?
Postgraduate Medical Journal 2008;84:2-3

Martin DS and Windsor J
From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia
Post Graduate Medical Journal 2008;84:622-627
>PubMed Link to this article

Plant T, Aref-Adib G
Travelling to new heights: practical high altitude medicine.
British Journal of Hospital Medicine. 2008;69(6):348-52.

Grocott M, Montgomery H.
Genetophysiology: Using Genetic Strategies to Explore Hypoxic Adaptation.
High Altitude Medicine and Physiology 2008;9:123-9

Wilson M, Milledge J.
Direct measurement of intracranial pressure at high altitude and correlation of ventricular size with acute mountain sickness: Brian Cummins' results from the 1985 Kishtwar expedition Neurosurgery 2008;63(5):970-5.

Grocott M, Montgomery H.
Genetophysiology: Using Genetic Strategies to Explore Hypoxic Adaptation.
High Altitude Medicine and Physiology 2008;9:123-9

Grocott MPW, Martin DS, Levett DZH, Montgomery H, Mythen MG.
Caudwell Xtreme Everest.
Anaesthesia and Analegesia 2008:6(4);Supp S81-84

Grocott MPW, Montgomery H, Vercueil A.
High Altitude Physiology and Pathophysiology: Implications and Relevance for Intensive Care Medicine.
Critical Care 2007;11(1):203

Rodway GW, Windsor JS, Hart ND; Caudwell Xtreme Everest Research Group.
Supplemental oxygen and hyperbaric treatment at high altitude: cardiac and respiratory response.
Aviation Space and Environmental Medicine 2007;78(6):613-7

Windsor JS, Rodway GW; Caudwell Xtreme Everest Research Group.
Supplemental oxygen effects on ventilation in acclimatized subjects exercising at 5700 m altitude.
Aviation Space and Environmental Medicine 2007;78(4):426-9pi

Rodway GW, Windsor JS, Hart ND; Caudwell Xtreme Everest Research Group.
Supplemental oxygen and hyperbaric treatment at high altitude: cardiac and respiratory response.
Aviation Space and Environmental Medicine 2007;78(6):613-7.

Windsor JS, Rodway GW; Caudwell Xtreme Everest Research Group.
Supplemental oxygen effects on ventilation in acclimatized subjects exercising at 5700 m altitude.
Aviation Space and Environmental Medicine 2007;78(4):426-9

Thompson J and Raitt J, Hutchings L, Bjargo E, Loset A, Grocott M and Montgomery H on behalf of the Xtreme Everest Research Group.
Angiotensin-converting enzyme genotype and successful ascent to extreme high altitude.
High Altitude Medicine and Biology 2007;8:278-285

Grocott MP, Johannson L.
Ketamine for emergency anaesthesia at very high altitude (4243 m above sea-level).

Anaesthesia. 2007;62(9):959-62

Grocott M, Richardson A, Montgomery H, Mythen M.
Caudwell Xtreme Everest: a field study of human adaptation to hypoxia.
Critical Care 2007;11(4):151

DS Martin, S McCorkell, A Vercueil, P Gunning, M Cox, J Dick, MG Mythen, MPW Grocott.
Increased gastric-end tidal PCO2 gap during exercise at high altitude: a tonometric study.

High Altitude Medicine and Biology 2007;8(1):50-5

Windsor JS, Rodway GW.
Heights and Haematology ? The Story of Haemoglobin at Altitude

Postgraduate Medical Journal 2007;83(977):148-51

Rodway GW, Windsor JS
Airway Mucociliary Function at High Altitude

Wilderness and Environmental Medicine 2006;17(4):271-5

Windsor JS, Rodway GW
Supplemental Oxygen and Sleep at Altitude

High Altitude Medicine and Biology 2006;7(4):307-11

Windsor J
Walking off the Map

British Medical Journal Apr 2006; 332:156-7

Windsor JS, Rodway GW, Dick J
The Use of Closed Circuit Oxygen in the Himalayas

High Altitude Medicine and Biology 2005;6(3) 28-30

Windsor JS, Roadway GW
Mt Kellas

High Altitude Medicine and Biology 2005;6(3) 270-1

Windsor JS, Rodway GW
Weight Loss at the Extremes

Journal of Nutritional and Environmental Medicine 2005;15(4):228-9

MPW Grocott, S McCorkell, ML Cox
Successful resuscitation from major upper gastrointestinal hemorrhage using rectally administered fluids in a wilderness environment: a case report.

Wilderness and Environmental Medicine 2005;16(4):209-11

Windsor J
The Presence of Painful Fissures at Altitude

British Journal of Dermatology 2002 Dec;147(6):1262

Windsor J, Montgomery H
Greater Awareness and Education are Needed to Help Prevent AMS

British Medical Journal 2001 Sep1;323(7311)514

PUBLISHED ABSTRACTS

Factors influencing acute mountain sickness in Nepal trekkers.

LD Johannson, MPW Grocott, G Engels, B Basnyat, MJ Poulin.
High Altitude Medicine and Biology 2006;7(4):319 -350


Case report of ventricular trigeminy at 4272 meters in Nepal.

LD Johannson, MPW Grocott.
High Altitude Medicine and Biology 2006;7(4):319 -350

LD Johannson, MPW Grocott
Case report of excellent outcome with Ketamine anaesthesia at 4272 meters in a rural setting in Nepal.

High Altitude Medicine and Biology 2006;7(4):319 -350

ABSTRACTS PRESENTED AT MEETINGS AND CONFRENCES

Matthew Sanborn, Heng Yow, Meeri Kim, Daniel Martin, Kay Mitchell, Mark Edsell.
Hyperventilation, acclimatization and cerebral oxygenation at altitude.
Presented at Hypoxia 2011, Lake Louise, Canada.

Michael PW Grocott, Denny ZH Levett, Rick Bezemer, Hugh E Montgomery, Daniel S Martin.
Near-infrared spectroscopy and a vascular occlusion test to study microvascular reactivity at high altitude
Presented at Hypoxia 2011, Lake Louise, Canada.

Michael PW Grocott, Mark Edsell, Ali Cobb, Kay Mitchell, Paula Meale, Daniel S Martin.
Systemic oxygen extraction during exercise at high altitude.
Presented at Hypoxia 2011, Lake Louise, Canada.

Matthew Sanborn, Meeri Kim, Heng Yow, Daniel Martin, Paula Meale, Mark Edsell.
Cerebral hemodynamics at altitude.
Presented at Hypoxia 2011, Lake Louise, Canada.

Jim Milledge, Nick Talbot, Edith Kortekaas, Dan Martin.
Reversal of hypoxic pulmonary hypertension by normoxia: a pilot study. Presented at Hypoxia 2011, Lake Louise, Canada.

George Rodway, Jeremy Windsor, Mike Grocott, Hugh Montgomery, Caudwell Xtreme Everest Research Group.
Electrocardiographic hanges in healthy individuals during a prolonged stay on Mt Everest.
Presented at Hypoxia 2011, Lake Louise, Canada.

Mark Edsell, Chris Imray, Mike Grocott and Mark Wilson for the Caudwell Xtreme Everest Research Group.
Changes in cerebral oximetry on ascent to altitude
Presented as a poster at Shock 2009
Published in Shock 2009; 32 (supp 1): 26

Arterial oxygen content on ascent to altitude

Martin D, Levett D, Grocott M.
Presented as a poster at the International Hypoxia Symposia 2009. Lake Louise, Canada. March 2009.

Reduced sublingual microcirculatory blood flow at altitude

Martin D , Goedhart P, Vercueil A, Levett D, Ince C, Grocott M.
Presented as a poster at the International Hypoxia Symposia 2009. Lake Louise, Canada. March 2009.

The Tight Fit Brain Hypothesis: No correlation between headache and anthropomorphically measured intracranial volume

Martin D, Kolfschoten N, Harvey J, Grocott, Wilson M.
Presented as a poster at the International Hypoxia Symposia 2009. Lake Louise, Canada. March 2009.

Gastric tonometry at rest and during exercise at 5100m

Stuart McCorkell, Michael Grocott, Daniel Martin, Mark Cox, John Dick, Paul Gunning, Andr? Vercueil, Monty Mythen.Presented as a poster at the Hypoxia meeting, Lake Louise, Canada, 2005.

The effect of acute hypoxia on coagulation in healthy subjects

John Dick, Gillian Ross, Stuart McCorkell, Monty Mythen
Presented as a poster at the Hypoxia meeting, Lake Louise, Canada, 2005.

The forgotten circuit - the use of closed oxygen circuits on Mount Everest

John Dick, Jeremy Windsor
Presented as a poster at the Hypoxia meeting, Lake Louise, Canada, 2005.

ACE genotype and Mount Evererest

G Tsianos, A Mynett, T Hubbart,S Grant, H Montgomery
Presented as a poster at the Hypoxia meeting, Lake Louise, Canada, 2005


Latest News

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Knowledge VII conference May 19th 2012

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KnO2wledge VI Conference 2011


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